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Article

Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants.

Nature communications - 28 Oct 2020

Weinmann Jonas, Weis Sabrina, Sippel Josefine, Tulalamba Warut, Remes Anca, El Andari Jihad, Herrmann Anne-Kathrin, Pham Quang H, Borowski Christopher, Hille Susanne, Schönberger Tanja, Frey Norbert, Lenter Martin, VandenDriessche Thierry, Müller Oliver J, Chuah Marinee K, Lamla Thorsten, Grimm Dirk

Abstract excerpt

Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products and for countless gene transfer vectors derived from natural or synthetic viral isolates that are under intense preclinical evaluation. Here, we report a versatile pipeline that enables the direct side-by-side comparison of pre-selected AAV capsids in high-throughput and in the same animal, by combining DNA/RNA barcoding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Barcoding, Taxonomic

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Source

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Identifiers

PMID: 33116134
DOI: 10.1038/s41467-020-19230-w
PMCID: PMC7595228

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