Article

Systematic multi-trait AAV capsid engineering for efficient gene delivery

2022-12-22

Abstract excerpt

Broadening gene therapy applications requires manufacturable vectors that efficiently transduce target cells in humans and preclinical models. Conventional selections of adeno-associated virus (AAV) capsid libraries are inefficient at searching the vast sequence space for the small fraction of vectors possessing multiple traits essential for clinical translation. Here, we present Fit4Function, a generalizable mach...

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Identifiers and source

Literature Corpus work: 4f24c078-21ef-5017-bfde-f479bcb54ea2
DOI: 10.1101/2022.12.22.521680

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