Article

Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-associated Virus Production

2023-07-19

Abstract excerpt

Manufacturing sufficient Adeno-Associated Virus (AAV) to meet current and projected clinical needs is a significant hurdle to the growing gene therapy industry. The recently discovered membrane-associated accessory protein (MAAP) is encoded by an alternative open reading frame in the AAV cap gene that is found in all presently reported natural serotypes. Recent evidence has emerged supporting a functional role of...

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Literature Corpus work: 1e83f238-10ca-5918-a914-8c9b1b141fad
DOI: 10.1101/2023.07.18.549400

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