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Multiparametric domain insertional profiling of adeno-associated virus VP1

26 Oct 2023

Abstract excerpt

Several evolved properties of adeno-associated virus (AAV), such as broad tropism and immunogenicity in humans, are barriers to AAV-based gene therapy. Most efforts to re-engineer these properties have focused on variable regions near AAV's 3-fold protrusions and capsid protein termini. To comprehensively survey AAV capsids for engineerable hotspots, we determined multiple AAV fitness phenotypes upon insertion of...

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PMID: 38027057
DOI: 10.1016/j.omtm.2023.101143

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