Adeno-Associated Virus Structural Biology as a Tool in Vector Development

doi:10.2217/fvl.13.112

Article

Adeno-Associated Virus Structural Biology as a Tool in Vector Development

28 Nov 2013

Abstract excerpt

Adeno-associated viruses (AAVs) have become important therapeutic gene delivery vectors in recent years. However, there are challenges, including intractable tissues/cell types and pre-existing immune responses, which need to be overcome for full realization of this system. This review addresses strategies aimed at improving AAV efficacy in the clinic through the creation of hybrid vectors that display altered or...

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