Article

Multiparametric domain insertional profiling of Adeno-Associated Virus VP1

2023-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Evolved properties of Adeno-Associated Virus (AAV), such as broad tropism and immunogenicity in humans, are barriers to AAV-based gene therapy. Previous efforts to re-engineer these properties have focused on variable regions near AAV’s 3-fold protrusions and capsid protein termini. To comprehensively survey AAV capsids for engineerable hotspots, we determined multiple AAV fitness phenotypes upo...

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Identifiers and source

Literature Corpus work: 70d9933c-0644-53ad-9d87-d7b153b81b7e
DOI: 10.1101/2023.04.19.537549

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