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Reprogramming Adeno-Associated Virus Tropism Via Displayed Peptides Tiling Receptor-Ligands

2022-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Adeno-associated viruses (AAVs) are common gene therapy vectors, however, their effectiveness is hindered by poor target tissue transduction and off-target delivery. Hypothesizing that naturally occurring receptor-ligand interactions could be repurposed to engineer tropism, we fragmented all annotated protein ligands known to bind human receptors into tiling 20-mer peptides and displayed these o...

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Identifiers and source

Literature Corpus work
12bea1c0-704a-5de8-bd46-85c5bef283b6
DOI
10.1101/2022.09.26.509383
Open publication

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Reprogramming Adeno-Associated Virus Tropism Via Displayed Peptides Tiling Receptor-LigandsDOI 10.1101/2022.09.26.509383
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