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Article

Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer.

Epigenetics - 1 Jan 2000

Medina Pedro P, Sanchez-Cespedes Montse, Cespedes Montse Sanchez

Abstract excerpt

The SWI/SNF complex is a chromatin-remodeling complex that uses the energy of ATP hydrolysis to modify chromatin structure in order to regulate gene expression. The SWI/SNF complex is evolutionarily conserved in all eukaryotes and is comprised of a catalytic subunit, either of BRG1 (also known as SMARCA4) or of BRM (also known as SMARCA2), and a variety of associated proteins that can modulate the recruitment of...

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Source

Identifiers

PMID: 18437052
DOI: 10.4161/epi.3.2.6153

Genes

SMARCA4
SMARCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer.PMID 18437052Read ↗

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Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomicsSemantic proximity Read ↗

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