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Article

The role of SMARCA4 in lung cancer

5 Aug 2025

Abstract excerpt

Lung cancer remains one of the leading causes of mortality among cancer patients. Chromatin remodeling is a crucial epigenetic process in cancer, primarily regulated by alterations in genes encoding subunits of the switch/sucrose non-fermentable (SWI/SNF) complex. SMARCA4 and SMARCA2 are two mutually exclusive catalytic subunits within the SWI/SNF complex responsible for utilizing ATP hydrolysis to provide energy...

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PMID: 40764807
DOI: 10.1038/s41598-025-13913-4

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