Article
BAFfling pathologies: Alterations of BAF complexes in cancer.
Cancer letters - 10 Apr 2018
Arnaud Ophelie, Le Loarer François, Tirode Franck
Abstract excerpt
To activate or repress specific genes, chromatin is constantly modified by chromatin-remodeling complexes. Among these complexes, the SWItch/Sucrose Non-Fermenting (SWI/SNF) complex, also referred to as BRG1-Associated Factor (BAF) complex, moves the nucleosome along chromatin using energy provided by ATP hydrolysis. In mammalian organisms, the SWI/SNF complex is composed of 10-15 subunits, depending on cell...
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