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Article

BAFfling pathologies: Alterations of BAF complexes in cancer.

Cancer letters - 10 Apr 2018

Arnaud Ophelie, Le Loarer François, Tirode Franck

Abstract excerpt

To activate or repress specific genes, chromatin is constantly modified by chromatin-remodeling complexes. Among these complexes, the SWItch/Sucrose Non-Fermenting (SWI/SNF) complex, also referred to as BRG1-Associated Factor (BAF) complex, moves the nucleosome along chromatin using energy provided by ATP hydrolysis. In mammalian organisms, the SWI/SNF complex is composed of 10-15 subunits, depending on cell...

Topics

Animals
Chromatin Assembly and Disassembly
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Humans
Mutation
Neoplasms
Nuclear Proteins
Nucleosomes
SMARCB1 Protein
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29374542
DOI: 10.1016/j.canlet.2018.01.046

Genes

SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29374542-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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