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Article

SMARCA4: Current status and future perspectives in non-small-cell lung cancer

28 Nov 2022

Abstract excerpt

SMARCA4, also known as transcription activator, is an ATP-dependent catalytic subunit of SWI/SNF (SWItch/Sucrose NonFermentable) chromatin-remodeling complexes that participates in the regulation of chromatin structure and gene expression by supplying energy. As a tumor suppressor that has aberrant expression in ∼10% of non-small-cell lung cancers (NSCLCs), SMARCA4 possesses many biological functions, including...

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PMID: 36450331
DOI: 10.1016/j.canlet.2022.216022

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