Article

In-Depth Characterization and Validation in <i>BRG1</i> -Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

2019-10-22

Abstract excerpt

Members of the ATP-dependent SWI/SNF chromatin remodeling complexes are among the most frequently mutated genes in cancer, suggesting their dysregulation plays a critical role. The synthetic lethality between SWI/SNF catalytic subunits BRM/SMARCA2 and BRG1/SMARCA4 has instigated great interest in targeting BRM. Here we have performed a critical and in-depth investigation of novel dual inhibitors (BRM011 and BRM014...

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Literature Corpus work: fd8f9050-ffe0-5abc-861c-8a1bf0d9da68
DOI: 10.1101/812628

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