Article
Heritable influence of DBH on adrenergic and renal function: twin and disease studies.
PloS one - 1 Jan 2013
Pasha Dalal N, Davis Jason T, Rao Fangwen, Chen Yuqing, Wen Gen, Fung Maple M, Mahata Manjula, Zhang Kuixing, Trzebinska Danuta, Mustapic Maja, Hightower C Makena, Lipkowitz Michael S, Ji Ming, Ziegler Michael G, Nievergelt Caroline M, O'Connor Daniel T
Abstract excerpt
BACKGROUND: Elevated sympathetic activity is associated with kidney dysfunction. Here we used twin pairs to probe heritability of GFR and its genetic covariance with other traits. METHODS: We evaluated renal and adrenergic phenotypes in twins. GFR was estimated by CKD-EPI algorithm. Heritability and genetic covariance of eGFR and associated risk traits were estimated by variance-components. Meta-analysis probed...
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