Article
Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.
Circulation - 28 Aug 2007
Rao Fangwen, Zhang Lian, Wessel Jennifer, Zhang Kuixing, Wen Gen, Kennedy Brian P, Rana Brinda K, Das Madhusudan, Rodriguez-Flores Juan L, Smith Douglas W, Cadman Peter E, Salem Rany M, Mahata Sushil K, Schork Nicholas J, Taupenot Laurent, Ziegler Michael G, O'Connor Daniel T
Abstract excerpt
BACKGROUND: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Does common genetic variation at human TH alter autonomic activity and predispose to cardiovascular disease? We undertook systematic polymorphism discovery at the TH locus and then tested variants for contributions to sympathetic function and blood pressure. METHODS AND RESULTS: We resequenced 80 ethnically diverse...
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