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Article

Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.

Journal of hypertension - 1 Jan 2010

Chen Yuqing, Wen Gen, Rao Fangwen, Zhang Kuixing, Wang Lei, Rodriguez-Flores Juan L, Sanchez Amber P, Mahata Manjula, Taupenot Laurent, Sun Ping, Mahata Sushil K, Tayo Bamidele, Schork Nicholas J, Ziegler Michael G, Hamilton Bruce A, O'Connor Daniel T

Abstract excerpt

RATIONALE: Dopamine beta-hydroxylase (DBH) plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine. Here we systematically investigated DBH polymorphisms associated with enzymatic activity as well as autonomic and blood pressure (BP)/disease phenotypes in vivo. METHODS AND RESULTS: Seventy genetic variants were discovered at the locus; across ethnicities, much of the promoter...

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Source

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Identifiers

PMID: 20009769
DOI: 10.1097/HJH.0b013e328332bc87
PMCID: PMC2860271

Genes

DBH
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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