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Dopamine beta‐hydroxylase and its genetic variants in human health and disease

15 Oct 2019

Abstract excerpt

Dopamine beta-hydroxylase (DβH) is an essential neurotransmitter-synthesizing enzyme that catalyzes the formation of norepinephrine (NE) from dopamine and has been extensively studied since its discovery in the 1950s. NE serves as a neurotransmitter in both the central and peripheral nervous systems and is the precursor to epinephrine synthesis in the brain and adrenal medulla. Alterations in noradrenergic...

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PMID: 31613389
DOI: 10.1111/jnc.14893

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