Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs.

doi:10.1124/jpet.109.157271

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs.

The Journal of pharmacology and experimental therapeutics - 1 Nov 2009

Rana Brinda K, Wessel Jennifer, Mahboubi Vafa, Rao Fangwen, Haeller Jeannine, Gayen Jiaur R, Eskin Eleazar, Valle Anne M, Das Madhusudan, Mahata Sushil K, Taupenot Laurent, Stridsberg Mats, Talley Todd T, Ziegler Michael G, Smith Douglas W, Schork Nicholas J, O'Connor Daniel T, Taylor Palmer

Abstract excerpt

Nicotinic acetylcholine receptors (nAChRs) are combinations of subunits arranged as pentamers encircling a central cation channel. At least nine alpha and four beta subunits are expressed in the central and peripheral nervous systems; their presence in autonomic ganglia, the adrenal medulla, and central nervous system, with accompanying responses elicited by nicotinic agonists, point to their involvement in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholinesterase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autonomic Nervous System

Share to Catecholamines

Share to Chromogranin A

Share to Chromogranins

Share to Chromosomes, Human, Pair 15

Share to Exocytosis

Share to Receptors, Nicotinic

Source

Open in PubMed Open full text

Identifiers

PMID: 19671882
DOI: 10.1124/jpet.109.157271
PMCID: PMC2775266

Genes

CHRNA3
CHRNB4
CHGA
CHRNA5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs.PMID 19671882Read ↗

Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution.Semantic proximity Read ↗

Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.Semantic proximity Read ↗

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Semantic proximity Read ↗

Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study.Semantic proximity Read ↗

Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.Semantic proximity Read ↗

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Semantic proximity Read ↗

Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension.Semantic proximity Read ↗

Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure.Semantic proximity Read ↗

Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease.Semantic proximity Read ↗

The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer.Semantic proximity Read ↗

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.Semantic proximity Read ↗

Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.