Article
Adrenergic polymorphism and the human stress response.
Annals of the New York Academy of Sciences - 1 Dec 2008
Rao Fangwen, Zhang Lian, Wessel Jennifer, Zhang Kuixing, Wen Gen, Kennedy Brian P, Rana Brinda K, Das Madhusudan, Rodriguez-Flores Juan L, Smith Douglas W, Cadman Peter E, Salem Rany M, Mahata Sushil K, Schork Nicholas J, Taupenot Laurent, Ziegler Michael G, O'Connor Daniel T
Abstract excerpt
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Does common genetic variation at human TH alter autonomic activity and predispose to cardiovascular disease? We undertook systematic polymorphism discovery at the TH locus, and then tested variants for contributions to sympathetic function and blood pressure. We resequenced 80 ethnically diverse individuals across the TH locus....
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