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Article

Genetic variation at the delta-sarcoglycan (SGCD) locus elevates heritable sympathetic nerve activity in human twin pairs.

Journal of neurochemistry - 1 Dec 2013

Hightower C Makena, Zhang Kuixing, Miramontes-González José P, Rao Fangwen, Wei Zhiyun, Schork Andrew J, Nievergelt Caroline M, Biswas Nilima, Mahata Manjula, Elkelis Nina, Taupenot Laurent, Stridsberg Mats, Ziegler Michael G, O'Connor Daniel T

Abstract excerpt

The Syrian Cardiomyopathic Hamster (BIO-14.6/53.58 strains) model of cardiac failure, resulting from naturally occurring deletion at the SGCD (delta-sarcoglycan) locus, displays widespread disturbances in catecholamine metabolism. Rare Mendelian myopathy disorders of human SGCD occur, although common naturally occurring SGCD genetic variation has not been evaluated for effects on human norepinephrine (NE)...

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Identifiers

PMID: 23786442
DOI: 10.1111/jnc.12346
PMCID: PMC3833977

Genes

SGCD
CHGB
CHGA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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