Article
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Dec 2009
Fung Maple M, Chen Yuqing, Lipkowitz Michael S, Salem Rany M, Bhatnagar Vibha, Mahata Manjula, Nievergelt Caroline M, Rao Fangwen, Mahata Sushil K, Schork Nicholas J, Brophy Victoria H, O'Connor Daniel T
Abstract excerpt
BACKGROUND: End-stage renal disease (ESRD) due to hypertension is common and displays familial aggregation in African Americans, suggesting genetic risk factors, including adrenergic activity alterations which are noted in both hypertension and ESRD. METHODS: We analysed 554 hypertensive nephrosclerosis participants (without clinically significant proteinuria) from the longitudinal National Institute of Diabetes...
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