Article
Sympathetic nervous system, genes and human essential hypertension.
Current neurovascular research - 1 Oct 2005
Zhu Haidong, Poole Joseph, Lu Yanhui, Harshfield Gregory A, Treiber Frank A, Snieder Harold, Dong Yanbin
Abstract excerpt
The sympathetic nervous system (SNS) is the first line of defense in the response to environmental stress through its regulation of second-to-second changes in blood pressure (BP). Both the activity of the SNS and the therapeutic responses to SNS agonists and antagonists are known to be highly variable in the population. "Small" changes caused by single nucleotide polymorphisms (SNPs) of SNS genes may have...
Topics
- Animals
- Autonomic Nervous System Diseases
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Hypertension
- Mutation
- Polymorphism, Single Nucleotide
- Receptors, Adrenergic
- Signal Transduction