Article
Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits.
Kidney international - 1 Nov 2009
Fung Maple M, Rana Brinda K, Tang Chih-Min, Shiina Tetsuo, Nievergelt Caroline M, Rao Fangwen, Salem Rany M, Waalen Jill, Ziegler Michael G, Insel Paul A, O'Connor Daniel T
Abstract excerpt
Because dopamine D(1) receptors (DRD1) influence renal sodium transport and vascular hemodynamics, we examined whether genetic polymorphisms play a role in renal function. We conducted polymorphism discovery across the DRD1 open reading frame and its 5'-UTR and then performed association studies with estimated glomerular filtration rate (eGFR), plasma creatinine (pCr), and fractional excretion of uric acid...
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