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Article

NOD2 is dispensable for ATG16L1 deficiency-mediated resistance to urinary tract infection.

Autophagy - 1 Feb 2014

Wang Caihong, Yuan Xuejun, Ma Emily, Mendonsa Graziella R, Plantinga Theo S, Kiemeney Lambertus A, Vermeulen Sita H, Mysorekar Indira U

Abstract excerpt

NOD2 (nucleotide-binding oligomerization domain containing 2) functions as a pathogen sensor and is involved in development of Crohn disease, a form of inflammatory bowel disease. NOD2 functions in concert with the autophagy protein ATG16L1, which is also implicated in Crohn disease. Recently, we identified a novel protective role of ATG16L1 deficiency in uropathogenic Escherichia coli-induced urinary tract...

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Identifiers

PMID: 24384785
DOI: 10.4161/auto.27196
PMCID: PMC5396096

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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