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Article

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease.

Mucosal immunology - 1 Sept 2011

Strober W, Watanabe T

Abstract excerpt

Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular sensor for small peptides derived from the bacterial cell wall component, peptidoglycan. Recent studies have uncovered unexpected functions of NOD2 in innate immune responses such as induction of type I interferon and facilitation of autophagy; moreover, they have disclosed extensive cross-talk between NOD2 and Toll-like receptors, which has...

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Share to Autophagy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Nod2 Signaling Adaptor Protein

Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 21750585
DOI: 10.1038/mi.2011.29
PMCID: PMC3773501

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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