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Article

Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohn's disease.

Immunological reviews - 1 Jul 2014

Strober Warren, Asano Naoki, Fuss Ivan, Kitani Atsushi, Watanabe Tomohiro

Abstract excerpt

The discovery that polymorphisms in the NOD2 (nucleotide-binding oligomerization domain containing 2) gene are associated with a greatly increased risk for the development of Crohn's disease has provided a means to achieve a deeper understanding of the dysregulation of mucosal immune responses to the commensal intestinal organisms that is thought to underlie this disease. NOD2 is a NOD-like receptor (NLR) family...

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Source

Identifiers

PMID: 24942694
DOI: 10.1111/imr.12193

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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