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Article

Role and molecular mechanism of NOD2 in chronic non-communicable diseases.

Journal of molecular medicine (Berlin, Germany) - 1 Jun 2024

Kong Lingjun, Cao Yanhua, He Yanan, Zhang Yahui

Abstract excerpt

Nucleotide-binding oligomerization domain containing 2 (NOD2), located in the cell cytoplasm, is a pattern recognition receptor belonging to the innate immune receptor family. It mediates the innate immune response by identifying conserved sequences in bacterial peptide glycans and plays an essential role in maintaining immune system homeostasis. Gene mutations of NOD2 lead to the development of autoimmune...

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PMID: 38740600
DOI: 10.1007/s00109-024-02451-7

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