Article
The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.
Immunity - 14 Nov 2013
Sorbara Matthew T, Ellison Lisa K, Ramjeet Mahendrasingh, Travassos Leonardo H, Jones Nicola L, Girardin Stephen E, Philpott Dana J
Abstract excerpt
The peptidoglycan sensor Nod2 and the autophagy protein ATG16L1 have been linked to Crohn's disease (CD). Although Nod2 and the related sensor, Nod1, direct ATG16L1 to initiate anti-bacterial autophagy, whether ATG16L1 affects Nod-driven inflammation has not been examined. Here, we uncover an unanticipated autophagy-independent role for ATG16L1 in negatively regulating Nod-driven inflammatory responses. Knockdown...
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