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Article

Nod2: The intestinal gate keeper

2 Mar 2017

Abstract excerpt

Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan (PGN)-conserved motifs in cytosol and stimulates host immune response. The association of NOD2 mutations with a number of inflammatory pathologies, including Crohn disease (CD), Graft-versus-host disease (GVHD), and Blau syndrome, highlights its pivotal role in host-pathogen...

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PMID: 28253332
DOI: 10.1371/journal.ppat.1006177

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