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Article

Bacterial invasion: linking autophagy and innate immunity.

Current biology : CB - 9 Feb 2010

Galluzzi Lorenzo, Kepp Oliver, Zitvogel Laurence, Kroemer Guido

Abstract excerpt

Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy.

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Source

Identifiers

PMID: 20144769
DOI: 10.1016/j.cub.2009.12.016

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Bacterial invasion: linking autophagy and innate immunity.PMID 20144769Read ↗

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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.Semantic proximity Read ↗

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ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis.Semantic proximity Read ↗

The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.Semantic proximity Read ↗

Crohn's disease: NOD2, autophagy and ER stress converge.Semantic proximity Read ↗

Autophagy and Crohns Disease: At the Crossroads of Infection, Inflammation, Immunity, and CancerSemantic proximity Read ↗

ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation.Semantic proximity Read ↗

Role of autophagy and autophagy genes in inflammatory bowel disease.Semantic proximity Read ↗

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Autophagy in Crohn’s Disease: Converging on Dysfunctional Innate ImmunitySemantic proximity Read ↗

The complex interplay of NOD-like receptors and the autophagy machinery in the pathophysiology of Crohn disease.Semantic proximity Read ↗

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