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Article

Innate Immune Sensing of Microbes by Nod Proteins

1 Aug 2006

Abstract excerpt

Nod1 and Nod2 are proteins involved in innate immune defense. These intracellular surveillance proteins detect bacterial peptidoglycan, although requiring distinct motifs to achieve sensing. Detection through Nod1 and Nod2 initiates proinflammatory signaling via NF-kappaB activation, which is necessary for clearance of infecting pathogens from the host. The peptidoglycan product sensed by Nod1 is a motif...

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PMID: 17057187
DOI: 10.1196/annals.1326.020

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