Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro.

PloS one - 1 Jan 2013

Lam Simon K W, Ma Xiaoli, Sing Tina L, Shilton Brian H, Brandl Christopher J, Davey Megan J

Abstract excerpt

The pre-sensor 1 (PS1) hairpin is found in ring-shaped helicases of the AAA+ family (ATPases associated with a variety of cellular activities) of proteins and is implicated in DNA translocation during DNA unwinding of archaeal mini-chromosome maintenance (MCM) and superfamily 3 viral replicative helicases. To determine whether the PS1 hairpin is required for the function of the eukaryotic replicative helicase,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Amino Acid Motifs
Share to Chromatography, Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Fungal

Share to Microbial Viability

Share to Mutagens

Share to Nucleic Acid Conformation

Share to Protein Subunits

Source

Open in PubMed Open full text

Identifiers

PMID: 24349215
DOI: 10.1371/journal.pone.0082177
PMCID: PMC3859580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro.PMID 24349215Read ↗

Functional conservation of beta-hairpin DNA binding domains in the Mcm protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae.Semantic proximity Read ↗

Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability.Semantic proximity Read ↗

Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.Semantic proximity Read ↗

Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.Semantic proximity Read ↗

Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.Semantic proximity Read ↗

A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.Semantic proximity Read ↗

The essential schizosaccharomyces pombe cdc23 DNA replication gene shares structural and functional homology with the Saccharomyces cerevisiae DNA43 (MCM10) gene.Semantic proximity Read ↗

Mcm10 mediates the interaction between DNA replication and silencing machineries.Semantic proximity Read ↗

The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication.Semantic proximity Read ↗

The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress.Semantic proximity Read ↗

The structure and function of MCM from archaeal M. Thermoautotrophicum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.