Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.

doi:10.1128/MCB.00033-20

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Article

Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.

Molecular and cellular biology - 29 Jun 2020

Kim Seong Min, Forsburg Susan L

Abstract excerpt

Upon replication fork arrest, the replication checkpoint kinase Cds1 is stimulated to preserve genome integrity. Robust activation of Cds1 in response to hydroxyurea prevents the endonuclease Mus81 from cleaving the stalled replication fork inappropriately. However, we find that the response is different in temperature-sensitive mcm4 mutants, affecting a subunit of the MCM replicative helicase. We show that Cds1...

Topics

Cell Cycle Checkpoints
Checkpoint Kinase 2
DNA Damage
DNA Replication
DNA, Fungal
Genome, Fungal
Genomic Instability
Minichromosome Maintenance Complex Component 4
Mutation
Schizosaccharomyces
Schizosaccharomyces pombe Proteins

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Identifiers

PMID: 32341083
DOI: 10.1128/MCB.00033-20
PMCID: PMC7324846

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