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Article

Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.

Molecular and cellular biology - 29 Jun 2020

Kim Seong Min, Forsburg Susan L

Abstract excerpt

Upon replication fork arrest, the replication checkpoint kinase Cds1 is stimulated to preserve genome integrity. Robust activation of Cds1 in response to hydroxyurea prevents the endonuclease Mus81 from cleaving the stalled replication fork inappropriately. However, we find that the response is different in temperature-sensitive mcm4 mutants, affecting a subunit of the MCM replicative helicase. We show that Cds1...

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Identifiers

PMID: 32341083
DOI: 10.1128/MCB.00033-20
PMCID: PMC7324846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.PMID 32341083Read ↗

Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.Semantic proximity Read ↗

Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.Semantic proximity Read ↗

Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint.Semantic proximity Read ↗

Regulation of DNA replication machinery by Mrc1 in fission yeast.Semantic proximity Read ↗

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Semantic proximity Read ↗

Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.Semantic proximity Read ↗

A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M.Semantic proximity Read ↗

Bloom's Syndrome Helicase and Mus81 are Required to Induce Transient Double-strand DNA Breaks in Response to DNA Replication StressSemantic proximity Read ↗

Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks.Semantic proximity Read ↗

Mus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiae.Semantic proximity Read ↗

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.Semantic proximity Read ↗

Checkpoint-independent scaling of the Saccharomyces cerevisiae DNA replication program.Semantic proximity Read ↗

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