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Article

The structure and function of MCM from archaeal M. Thermoautotrophicum.

Nature structural biology - 1 Mar 2003

Fletcher Ryan J, Bishop Brooke E, Leon Ronald P, Sclafani Robert A, Ogata Craig M, Chen Xiaojiang S

Abstract excerpt

Eukaryotic chromosomal DNA is licensed for replication precisely once in each cell cycle. The mini-chromosome maintenance (MCM) complex plays a role in this replication licensing. We have determined the structure of a fragment of MCM from Methanobacterium thermoautotrophicum (mtMCM), a model system for eukaryotic MCM. The structure reveals a novel dodecameric architecture with a remarkably long central channel....

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Source

Identifiers

PMID: 12548282
DOI: 10.1038/nsb893

Genes

MCM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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