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Article

Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.

Genetics - 1 Oct 2001

Liang D T, Forsburg S L

Abstract excerpt

MCM proteins are required for the proper regulation of DNA replication. We cloned fission yeast mcm7(+) and showed it is essential for viability; spores lacking mcm7(+) begin S phase later than wild-type cells and arrest with an apparent 2C DNA content. We isolated a novel temperature-sensitive allele, mcm7-98, and also characterized two temperature-sensitive alleles of the fission yeast homolog of MCM10,...

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Source

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Identifiers

PMID: 11606526
DOI: 10.1093/genetics/159.2.471
PMCID: PMC1461838

Genes

MCM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.PMID 11606526Read ↗

Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay.Semantic proximity Read ↗

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The essential schizosaccharomyces pombe cdc23 DNA replication gene shares structural and functional homology with the Saccharomyces cerevisiae DNA43 (MCM10) gene.Semantic proximity Read ↗

Fission yeast cdc24 is a replication factor C- and proliferating cell nuclear antigen-interacting factor essential for S-phase completion.Semantic proximity Read ↗

A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.Semantic proximity Read ↗

Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity.Semantic proximity Read ↗

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Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe.Semantic proximity Read ↗

Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.Semantic proximity Read ↗

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Semantic proximity Read ↗

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