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Article

Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.

Molecular and cellular biology - 1 Jun 2015

Tsai Feng-Ling, Vijayraghavan Sriram, Prinz Joseph, MacAlpine Heather K, MacAlpine David M, Schwacha Anthony

Abstract excerpt

The DNA replication checkpoint (DRC) monitors and responds to stalled replication forks to prevent genomic instability. How core replication factors integrate into this phosphorylation cascade is incompletely understood. Here, through analysis of a unique mcm allele targeting a specific ATPase active site (mcm2DENQ), we show that the Mcm2-7 replicative helicase has a novel DRC function as part of the signal...

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Identifiers

PMID: 25870112
DOI: 10.1128/MCB.01357-14
PMCID: PMC4438241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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