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Article

Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

G3 (Bethesda, Md.) - 13 Oct 2016

Ranatunga Nimna S, Forsburg Susan L

Abstract excerpt

The minichromosome maintenance (MCM) complex is the conserved helicase motor of the eukaryotic replication fork. Mutations in the Mcm4 subunit are associated with replication stress and double strand breaks in multiple systems. In this work, we characterize a new temperature-sensitive allele of Schizosaccharomyces pombe mcm4+ Uniquely among known mcm4 alleles, this mutation causes sensitivity to the alkylation...

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Share to Antineoplastic Agents, Alkylating
Share to Chromosome Segregation
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Methyl Methanesulfonate

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Source

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Identifiers

PMID: 27473316
DOI: 10.1534/g3.116.033571
PMCID: PMC5068930

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.PMID 27473316Read ↗

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