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Article

Functional conservation of beta-hairpin DNA binding domains in the Mcm protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae.

Genetics - 1 Aug 2008

Leon Ronald P, Tecklenburg Marianne, Sclafani Robert A

Abstract excerpt

Mcm proteins are an important family of evolutionarily conserved helicases required for DNA replication in eukaryotes. The eukaryotic Mcm complex consists of six paralogs that form a heterohexameric ring. Because the intact Mcm2-7 hexamer is inactive in vitro, it has been difficult to determine the precise function of the different subunits. The solved atomic structure of an archaeal minichromosome maintenance...

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Identifiers

PMID: 18660534
DOI: 10.1534/genetics.108.088690
PMCID: PMC2516056

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