Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gata2 is required for HSC generation and survival.

The Journal of experimental medicine - 16 Dec 2013

de Pater Emma, Kaimakis Polynikis, Vink Chris S, Yokomizo Tomomasa, Yamada-Inagawa Tomoko, van der Linden Reinier, Kartalaei Parham Solaimani, Camper Sally A, Speck Nancy, Dzierzak Elaine

Abstract excerpt

Knowledge of the key transcription factors that drive hematopoietic stem cell (HSC) generation is of particular importance for current hematopoietic regenerative approaches and reprogramming strategies. Whereas GATA2 has long been implicated as a hematopoietic transcription factor and its dysregulated expression is associated with human immunodeficiency syndromes and vascular integrity, it is as yet unknown how...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Separation
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to GATA2 Transcription Factor

Share to Gene Deletion

Share to Gene Expression Regulation, Developmental

Share to Hematopoietic Stem Cells

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 24297996
DOI: 10.1084/jem.20130751
PMCID: PMC3865477

Genes

GATA2
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gata2 is required for HSC generation and survival.PMID 24297996Read ↗

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.Semantic proximity Read ↗

Identification of the niche and phenotype of the first human hematopoietic stem cells.Semantic proximity Read ↗

<i>Gata2</i> -regulated <i>Gfi1b</i> expression controls endothelial programming during endothelial-to-hematopoietic transitionSemantic proximity Read ↗

The genesis of human hematopoietic stem cellsSemantic proximity Read ↗

Single-cell tracing of the first hematopoietic stem cell generation in human embryosSemantic proximity Read ↗

Induction of a hemogenic program in mouse fibroblasts.Semantic proximity Read ↗

In vivo single cell analysis reveals Gata2 dynamics in cells transitioning to hematopoietic fate.Semantic proximity Read ↗

Development of Hematopoietic Stem Cells in the Human EmbryoSemantic proximity Read ↗

Gata3 targets Runx1 in the embryonic haematopoietic stem cell nicheSemantic proximity Read ↗

Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling.Semantic proximity Read ↗

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignanciesSemantic proximity Read ↗

Generation and Analysis of GATA2w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.