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Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies

5 Apr 2012

Abstract excerpt

Numerous examples exist of how disrupting the actions of physiological regulators of blood cell development yields hematologic malignancies. The master regulator of hematopoietic stem/progenitor cells GATA-2 was cloned almost 20 years ago, and elegant genetic analyses demonstrated its essential function to promote hematopoiesis. While certain GATA-2 target genes are implicated in leukemogenesis, only recently...

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PMID: 22492510
DOI: 10.1093/nar/gks281

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