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The genesis of human hematopoietic stem cells

20 Jun 2023

Abstract excerpt

Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic waves that generate the differentiated blood cells required for embryonic development while establishing a pool of undifferentiated hematopoietic stem cells (HSCs) for postnatal life. This multilayered design in which active hematopoiesis migrates through diverse extra and intraembryonic tissues has made it difficult to define a...

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PMID: 37339578
DOI: 10.1182/blood.2022017934

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