Article

Development of Hematopoietic Stem Cells in the Human Embryo

2018-11-29

Abstract excerpt

Abstract Haematopoietic stem cells (HSCs) develop intra-embryonically in the aorta-gonad-mesonephros (AGM) region, more specifically in the ventral domain of the embryonic dorsal aorta. This process is highly conserved across vertebrate species. Key transcription factors and signalling pathways involved in HSC development have been identified using various model organisms. As a mammal, the mouse represents an exce...

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Literature Corpus work: 22d21364-6cb0-520d-b9d2-2818c0b95939
DOI: 10.1182/blood-2018-99-109423

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