Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of a hemogenic program in mouse fibroblasts.

Cell stem cell - 1 Aug 2013

Pereira Carlos-Filipe, Chang Betty, Qiu Jiajing, Niu Xiaohong, Papatsenko Dmitri, Hendry Caroline E, Clark Neil R, Nomura-Kitabayashi Aya, Kovacic Jason C, Ma'ayan Avi, Schaniel Christoph, Lemischka Ihor R, Moore Kateri

Abstract excerpt

Definitive hematopoiesis emerges during embryogenesis via an endothelial-to-hematopoietic transition. We attempted to induce this process in mouse fibroblasts by screening a panel of factors for hemogenic activity. We identified a combination of four transcription factors, Gata2, Gfi1b, cFos, and Etv6, that efficiently induces endothelial-like precursor cells, with the subsequent appearance of hematopoietic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Cell Membrane

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Aggregation

Share to Colony-Forming Units Assay

Share to Endothelial Cells

Share to Fibroblasts

Share to Green Fluorescent Proteins

Share to Hematopoiesis

Source

Open in PubMed Open full text

Identifiers

PMID: 23770078
DOI: 10.1016/j.stem.2013.05.024
PMCID: PMC3735774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of a hemogenic program in mouse fibroblasts.PMID 23770078Read ↗

Cooperative Transcription Factor Induction Mediates Hemogenic ReprogrammingSemantic proximity Read ↗

An expandable, inducible hemangioblast state regulated by fibroblast growth factor.Semantic proximity Read ↗

Generation and Analysis of GATA2w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis.Semantic proximity Read ↗

Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor PotentialSemantic proximity Read ↗

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.Semantic proximity Read ↗

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1Semantic proximity Read ↗

A Highly Efficient Aorta-Gonad-Mesonephros-Like Definitive Hemogenic Endothelium From Human Pluripotent Stem CellsSemantic proximity Read ↗

Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic TransitionSemantic proximity Read ↗

Enforced activation of STAT5A facilitates the generation of embryonic stem-derived hematopoietic stem cells that contribute to hematopoiesis in vivo.Semantic proximity Read ↗

Single-cell tracing of the first hematopoietic stem cell generation in human embryosSemantic proximity Read ↗

Arterial cells support the development of human hematopoietic progenitors in vitro via secretion of IGFBP2Semantic proximity Read ↗

Gata2 is required for HSC generation and survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.