Article

<i>Gata2</i> -regulated <i>Gfi1b</i> expression controls endothelial programming during endothelial-to-hematopoietic transition

2022-03-27

Abstract excerpt

The first hematopoietic stem cells (HSCs) are formed through endothelial-to-hematopoietic transition (EHT) events during embryonic development. The transcription factor GATA2 is a crucial regulator of EHT and HSC function throughout life. Because GATA2 haploinsufficiency patients have inborn mutations, prenatal defects are likely to have an influence on disease development. In mice, Gata2 haploinsufficiency (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 646720e9-9fcb-539c-b7d2-ba1c9ede9efc
DOI: 10.1101/2022.03.24.485642

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Gata2</i> -regulated <i>Gfi1b</i> expression controls endothelial programming during endothelial-to-hematopoietic transitionDOI 10.1101/2022.03.24.485642Read

Generation and Analysis of GATA2w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis.Semantic proximity Read

A<i>Gata2</i>intronic enhancer confers its pan-endothelia-specific regulationSemantic proximity Read

Gata2 is required for HSC generation and survival.Semantic proximity Read

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.Semantic proximity Read

Induction of a hemogenic program in mouse fibroblasts.Semantic proximity Read

CD82 expression marks the endothelium to hematopoietic transition at the onset of blood specification in humanSemantic proximity Read

Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafishSemantic proximity Read

GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene.Semantic proximity Read

Roles of Hematopoietic Transcription Factors GATA-1 and GATA-2 in the Development of Red Blood Cell LineageSemantic proximity Read

MEIS2 regulates endothelial to hematopoietic transition of human embryonic stem cells by targeting TAL1Semantic proximity Read

Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endotheliumSemantic proximity Read

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignanciesSemantic proximity Read