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Article

Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche

21 Oct 2019

Abstract excerpt

Abstract Runx1 is an important haematopoietic transcription factor as stressed by its involvement in a number of haematological malignancies. Furthermore, it is a key regulator of the emergence of the first haematopoietic stem cells (HSCs) during development. The transcription factor Gata3 has also been linked to haematological disease and was shown to promote HSC production in the embryo by inducing the...

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PMID: 31634421
DOI: 10.1002/iub.2184

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