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Article

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.

The Journal of experimental medicine - 16 Dec 2013

Gao Xin, Johnson Kirby D, Chang Yuan-I, Boyer Meghan E, Dewey Colin N, Zhang Jing, Bresnick Emery H

Abstract excerpt

The generation of hematopoietic stem cells (HSCs) from hemogenic endothelium within the aorta, gonad, mesonephros (AGM) region of the mammalian embryo is crucial for development of the adult hematopoietic system. We described a deletion of a Gata2 cis-element (+9.5) that depletes fetal liver HSCs, is lethal at E13-14 of embryogenesis, and is mutated in an immunodeficiency that progresses to...

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Identifiers

PMID: 24297994
DOI: 10.1084/jem.20130733
PMCID: PMC3865483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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