Article
Identification of the niche and phenotype of the first human hematopoietic stem cells.
Stem cell reports - 8 Apr 2014
Ivanovs Andrejs, Rybtsov Stanislav, Anderson Richard A, Turner Marc L, Medvinsky Alexander
Abstract excerpt
In various vertebrate species, the dorsal aorta (Ao) is the site of specification of adult hematopoietic stem cells (HSCs). It has been observed that the upregulation of essential hematopoietic transcription factors and the formation of specific intra-aortic hematopoietic cell clusters occur predominantly in the ventral domain of the Ao (AoV). In the mouse, the first HSCs emerge in the AoV. Here, we demonstrate...
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