Article
Generation and Analysis of GATA2w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis.
Stem cell reports - 8 Nov 2016
Huang Ke, Gao Jiao, Du Juan, Ma Ning, Zhu Yanling, Wu Pengfei, Zhang Tian, Wang Wenqian, Li Yuhang, Chen Qianyu, Hutchins Andrew Paul, Yang Zhongzhou, Zheng Yi, Zhang Jian, Shan Yongli, Li Xuejia, Liao Baojian, Liu Jiajun, Wang Jinyong, Liu Bing, Pan Guangjin
Abstract excerpt
The transition from hemogenic endothelial cells (HECs) to hematopoietic stem/progenitor cells (HS/PCs), or endothelial to hematopoietic transition (EHT), is a critical step during hematopoiesis. However, little is known about the molecular determinants of HECs due to the challenge in defining HECs. We report here the generation of GATA2w/eGFP reporter in human embryonic stem cells (hESCs) to mark cells expressing...
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