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Article

One-carbon metabolism pathway gene variants and risk of clear cell renal cell carcinoma in a Chinese population.

PloS one - 1 Jan 2013

Zhang Lei, Meng Xiaoxin, Ju Xiaobing, Cai Hongzhou, Li Pu, Cao Qiang, Shao Pengfei, Qin Chao, Yin Changjun

Abstract excerpt

BACKGROUND: One-carbon metabolism is the basement of nucleotide synthesis and the methylation of DNA linked to cancer risk. Variations in one-carbon metabolism genes are reported to affect the risk of many cancers, including renal cancer, but little knowledge about this mechanism is known in Chinese population. METHODS: Each subject donated 5 mL venous blood after signing the agreement. The study was approved by...

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Source

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Identifiers

PMID: 24278388
DOI: 10.1371/journal.pone.0081129
PMCID: PMC3837692

Genes

CBS
MTRR
MTHFR
MTR
SHMT1
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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