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Genetic Variants in One-Carbon Metabolism Pathway Predict Survival Outcomes of Early-Stage Non-Small Cell Lung Cancer.

Oncology - 1 Jan 2020

Do Sook Kyung, Choi Sun Ha, Lee Shin Yup, Choi Jin Eun, Kang Hyo-Gyoung, Hong Mi Jeong, Kim Ji Hyun, Baek Sun Ah, Lee Jang Hyuck, Lee Won Kee, Do Young Woo, Lee Eung Bae, Shin Kyung Min, Jeong Ji Yun, Lee Yong Hoon, Seo Hyewon, Yoo Seung Soo, Lee Jaehee, Cha Seung Ick, Kim Chang Ho, Seok Yangki, Cho Sukki, Jheon Sanghoon, Park Jae Yong

Abstract excerpt

BACKGROUND: This study was conducted to investigate the association between genetic variants in one-carbon metabolism and survival outcomes of surgically resected non-small cell lung cancer (NSCLC). METHODS: We genotyped 41 potentially functional variants of 19 key genes in the one-carbon metabolism pathway among 750 NSCLC patients who underwent curative surgery. The association between genetic variants and...

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PMID: 32791502
DOI: 10.1159/000509658

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