Article
Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population.
PloS one - 1 Jan 2014
Chang Shen-Chih, Chang Po-Yin, Butler Brendan, Goldstein Binh Y, Mu Lina, Cai Lin, You Nai-Chieh Y, Baecker Aileen, Yu Shun-Zhang, Heber David, Lu Qing-Yi, Li Liming, Greenland Sander, Zhang Zuo-Feng
Abstract excerpt
One-carbon metabolism (folate metabolism) is considered important in carcinogenesis because of its involvement in DNA synthesis and biological methylation reactions. We investigated the associations of single nucleotide polymorphisms (SNPs) in folate metabolic pathway and the risk of three GI cancers in a population-based case-control study in Taixing City, China, with 218 esophageal cancer cases, 206 stomach...
Topics
- Aged
- Asian People
- Case-Control Studies
- China
- Esophageal Neoplasms
- Female
- Ferredoxin-NADP Reductase
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans